Skip to main content
Health & Nutrition
Zaheera Swing
Nutritional Therapist & Herbalist BSc Hons Nutritional Science + NTPD

Glucosamine For Arthritis: Health Benefits, How To Use, Dosage, Side Effects & Safety

Glucosamine, a natural amino sugar found in the human body, is essential for building cartilage, ligaments, and other joint structures. It's commonly used in supplement form alongside chondroitin, to manage osteoarthritis and support joint health. Benefits include alleviating osteoarthritis symptoms, promoting joint and skin health, and joint pain relief. Glucosamine is typically taken in dosages of 1,500 mg daily, and is generally safe but may cause side effects like nausea or heartburn. 


What Is Glucosamine?



Glucosamine is an amino sugar naturally found in the human body, primarily in the fluid around the joints and within the cartilage. It plays a crucial role in building cartilage, ligaments, tendons, and the thick fluid that surrounds joints, known as synovial fluid. As we age, the amount of glucosamine our body produces decreases, leading to a gradual breakdown of these joint structures.

So, where does glucosamine come from? Glucosamine is commonly sourced from the shells of shellfish, however it can also be made in a lab. Glucosamine supplements are widely used to help manage osteoarthritis, a degenerative joint disease in which cartilage gets worn down at the ends of the bones, and to support overall joint health and comfort.

Glucosamine contains active components that are believed to aid in the repair of cartilage, reduce inflammation, and improve joint mobility. Clinical studies suggest that it may provide relief from joint pain, swelling, and stiffness related to osteoarthritis [1].

Since glucosamine has powerful anti-inflammatory and cartilage-supporting properties, it is popularly referred to as the gold standard in natural joint support. It is commonly combined with chondroitin sulfate, another natural compound and building block for cartilage, to enhance its efficacy.

In this article, we provide detailed information on the health benefits and use of glucosamine supplementation. Let's dive in.




What Are The Health Benefits of Glucosamine?


1. Alleviates Osteoarthritis Pain & Symptoms



Glucosamine supplements can relieve pain and stiffness associated with osteoarthritis and rheumatoid arthritis, according to research. A review of randomized controlled trials found that glucosamine can significantly reduce pain and improve physical function in individuals with osteoarthritis. Some studies have also shown that glucosamine may slow down the progression of osteoarthritis and protect joint cartilage. [2] [3]

For example, a study over 2.5 years found that women who took1500mg of glucosamine daily reduced their risk of developing knee osteoarthritis significantly compared to the placebo group. [4]

However, it is important to note that not all studies have shown consistent results, and the effectiveness of glucosamine supplements may vary from person to person.



2. Supports Joint Health



Regular intake of glucosamine may aid in maintaining healthy cartilage in the joints. It is believed to support cartilage repair and maintenance by stimulating cells to produce complex carbohydrate molecules known as glycosaminoglycans (GAGs) and proteoglycans which provide the joints with shock-absorbing qualities, which is particularly beneficial for knee pain. [5] 



3. Reduces Inflammation



Glucosamine possesses anti-inflammatory properties that may help in reducing joint inflammation, thereby offering relief from symptoms like swelling, pain, and stiffness.

For example, researchers found that taking glucosamine and chondroitin supplementation can help reduce levels of the pro-inflammatory chemical known as C-Reactive Protein by up to 36%! [6] 



4. Boosts Gut Health



Glucosamine provides fuel for the friendly bacteria in the gut. That means it promotes a more balanced composition of the gut flora, positively impacting overall health and wellbeing [7]. A healthy gut microbiome can also help protect against intestinal permeability, also known as “leaky gut,” associated with inflammation and even joint conditions like rheumatoid arthritis! [8]



4. Benefits Skin Health



Emerging research on glucosamine suggests that when glucosamine is used topically in the form of n-acetyl glucosamine it can promote skin health by stimulating the production of hyaluronic acid – a compound that keeps the skin hydrated and may help reduce the appearance of wrinkles. [9]




How To Use Glucosamine



Glucosamine supplements are available in various forms, including tablets, capsules, powders, and even as topical creams. While oral supplements are the most popular, it's essential to choose a form that aligns with your needs and preferences.

For optimal results, it is recommended to take glucosamine supplements with food, which may help to reduce the possibility of gastrointestinal side effects.


What is the right glucosamine dosage?


The recommended dosage of glucosamine for adults is 1,500 mg per day, which can be taken all at once or divided into multiple doses, according the The Arthritis Foundation.

It's still recommended to consult with a healthcare provider to determine the right dosage for your unique needs.



Is it okay to take glucosamine everyday?


Taking glucosamine daily is generally considered safe. Many high quality research studies have included participants taking glucosamine for up to 3 years, with no serious adverse effects. 




Safety & Side Effects of Glucosamine


Glucosamine supplements are generally considered safe for most people. However, like any supplement, it's crucial to be aware of potential side effects and contraindications.

Possible side effects include:

  • Nausea
  • Heartburn
  • Diarrhea
  • Constipation



Who should not take glucosamine?


Those allergic to shellfish should choose a vegetarian or synthetic form of glucosamine. Glucosamine also might worsen asthma symptoms and could raise pressure in the eyes, therefore it's recommended that individuals with glaucoma avoid taking supplements containing glucosamine.

Individuals on blood thinning medication are advised to avoid glucosamine supplements, since they may increase the risk of bleeding and bruising when taken together.

Pregnant and breastfeeding women should consult with a doctor before taking taking glucosamine.



What's the difference between glucosamine sulfate and glucosamine hydrochloride?


Glucosamine sulfate is bound to a sulfate molecule and provides necessary sulfur for cartilage repair, while glucosamine hydrochloride is tied to a hydrochloride molecule and often offers a higher concentration of glucosamine.

Some research suggests that glucosamine sulfate might be more effective in alleviating osteoarthritis symptoms. Both forms are generally well-tolerated, with similar potential side effects.




NutriRise Glucosamine and Chondroitin: The Superior Choice



NutriRise is a health and wellness brand providing dietary supplements to support the health of your mind, body, and spirit, including our top-selling Glucosamine and Chondroitin supplement: Joint Flex used by thousands of happy customers.

Co-founders Basim & Ramsha Mirza started NutriRise in 2016, fuelled by the desire to transform their own health through the power of nutrition and ancient wisdom. NutriRise is now backed by a world-class team of researchers, chemists, biologists, doctors, and nutritionists. Every supplement we provide is produced in the USA in a CGMP-certified facility for unparalleled safety, purity, and quality.

At NutriRise, we ensure the quality and effectiveness of our Glucosamine Chondroitin by rigorous third-party testing. This stringent protocol helps us guarantee that the Glucosamine Chondroitin we offer is of the highest standard. 

We also ensure you're getting the most potent and effective form of Glucosamine and other joint supporting herbs and nutrients by using the latest research to ensure optimal dosage and bioavailability. This delivers the perfect, safe amount of glucosamine, chondroitin, turmeric, MSM, boswellia, quercetin, methionine and bromelain for optimal joint support and relief from common arthritis symptoms.

Finally, we go beyond just creating and selling products; at NutriRise, we care deeply about the customer experience too. Through our efficient delivery system, we ensure your Glucosamine Chondroitin reaches you in perfect condition. By choosing NutriRise, you can trust in the quality and potency of each product, from our meticulous production processes to its arrival at your doorstep!




Key Points:


  • Glucosamine is a natural amino sugar that's essential for building cartilage and other structures in human joints.

  • This compound is typically sourced from shellfish, but it can also be synthesized in laboratories.

  • Its numerous benefits include alleviating pain associated with osteoarthritis, bolstering joint health, enhancing gut health, and improving skin health.

  • For adults, the recommended daily dosage is 1,500 mg, and it's best taken with food to minimize potential gastrointestinal side effects.

  • While glucosamine is generally considered safe, some individuals might experience side effects such as nausea or heartburn.

  • Those who are allergic to shellfish, have asthma, or are on blood thinners should exercise caution.



Note: This article is for informational purposes only and not intended for use as medical advice or to treat osteoarthritis. Always consult your healthcare provider before starting any dietary supplement.

Zaheera Swing
Nutritional Therapist & Herbalist BSc Hons Nutritional Science + NTPD
As a qualified Nutritional Therapist (BSc Hons Nutritional Science + NTPD), Zaheera Swing has a deep passion for restoring balance and harmony to the body through the modalities of nutritional science, herbalism, and holistic lifestyle practices. Using the functional medicine model coupled with wisdom from ancient paradigms, she aims to provide insight into the underlying root causes of poor health and the holistic tools we can harness to enhance the well-being of mind, body, and spirit.
Learn More

Featured Article


Dive deep into the NutriRise products, ancient wisdom, and abundant living with co-founders Basim & Ramsha Mirza

More on this

Your source for abundant living
Get the latest NutriRise recipes, videos & offers delivered to your inbox

Your Cart

Your cart is currently empty.
Click here to continue shopping.
Thanks for contacting us! We'll get back to you shortly. Thanks for subscribing Thanks! We will notify you when it becomes available! The max number of items have already been added There is only one item left to add to the cart There are only [num_items] items left to add to the cart